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10.1016/j.bbamem.2018.06.014 66 LaporteA.LortzS.SchaalC.LenzenS.ElsnerM

The following was calculated for [C 19 H 13 Cl 2 N 2 O] + : 355.0405, found: 355.0400: 1 H NMR (600 MHz, CDCl 3 ) 13.14 (s, 1H), 8.46 (d, J = 7.3 Hz, 1H), 7.93 (d, J = 9.2 Hz, 1H), 7.85 (d, J = 7.4 Hz, 2H), 7.66 (d, J = 2.2 Hz, 1H), 7.48 (t, J = 7.6 Hz, 2H), 7.39 (d, J = 2.2 Hz, 1H), 7.36 (t, J = 7.4 Hz, 1H), 6.96 (dd, J = 9.1, 6.4 Hz, 1H), 6.83 (t, J = 6.8 Hz, 1H)

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In CXBK mice (a recombinant-inbred strain insensitive to morphine), as well as in mice treated with antisense probes targeting exon-1 of the MOP gene, the analgesic effect of morphine is suppressed while that of heroin and M6G is retained [87]